Elucidating pathway arsenic methylation


15-Mar-2016 12:59

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(A metal has luster, conducts heat and electricity, and is malleable and ductile.

Elemental arsenic tends to be nonductile.) In the environment, arsenic is found in inorganic and organic forms and in different valence or oxidation states. In this review, we will be focused on the arsenicals in the trivalent and pentavalent states that are found in the environment and to which humans are exposed.

Environmentally relevant forms of arsenic are inorganic and organic existing in the trivalent or pentavalent state.

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The most visible symptoms of acute arsenic poisoning—nausea, vomiting, diarrhea, and abdominal pain—could be easily confused with other common diseases at the time (e.g., cholera and pneumonia) (ATSDR, 2007b).Depending on the dose, chronic arsenic exposure may affect several major organ systems.A major concern of ingested arsenic is cancer, primarily of skin, bladder, and lung.This is because arsenic has a long history of being a poison, both intentional and unintentional, to humans.

However, most laymen do not know or understand that we are constantly exposed to arsenic because it is naturally present in the environment, is used in commercial products, and has medical applications.The mode of action of arsenic for its disease endpoints is currently under study.



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